From Stress to Anhedonia: Molecular Processes through Functional Circuits

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Converging evidence across species highlights the contribution of environmental stress
to anhedonia (loss of pleasure and/or motivation). However, despite a clear link between
stress and the emergence of anhedonic-like behavior in both human and animal models,
the underlying biological pathways remain elusive. Here, we synthesize recent findings
across multiple levels, from molecular signaling pathways through whole-brain networks,
to discuss mechanisms through which stress may influence anhedonia.

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