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Production of Protein-Complex Components Is Stoichiometric and Lacks General Feedback Regulation in Eukaryotes

Careful reanalysis of ribosome profiling data revealed proportional synthesis for the vast majority of protein complexes in budding yeast and…

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Careful reanalysis of ribosome profiling data revealed proportional synthesis for
the vast majority of protein complexes in budding yeast and large complexes in higher
eukaryotes. Furthermore, systematic perturbation to chromosome copy number demonstrated
that precise rates of protein synthesis are hard coded in the genome rather than actively
monitored and maintained through feedback.